Chemotherapy for Colon Cancer

Influence of age on treatment options

Commentator: STEVEN ALBERTS, MD

Comment:

If the patient had been in her late fifties instead of late thirties and had this same three lung nodule recurrence, I would have still used the same treatment, provided the fairly quick recurrence. If the lung nodules appeared two years after the chemotherapy had been received, I would have been more in favor of observing the patient and using chemotherapy at a time of further recurrent disease.

Use of FOLFIRI versus FOLFOX as treatment after prior FOLFOX

Commentator: STEVEN CURLEY, MD

Comment:

Since the patient already received FOLFOX as adjuvant treatment after hemicolectomy, we felt that it would be better to use something new. Based on her K-ras wild-type status, FOLFIRI with cetuximab was selected because good responses have been shown in properly selected patients. Since she had had a full course of FOLFOX previously, the use of FOLFOX was not preferable when she developed metastatic disease.

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